Table 2:
Histopathological Characteristics of IDH1 Mutant and IDH Wild Type Intrahepatic Cholangiocarcinoma, small duct typea
| Variable | Wild type IDH N = 65 |
Mutant IDH1 N = 25 |
p-value |
|---|---|---|---|
| Median tumor size (cm, range) | 6.0 (4.2, 8.4) | 5.5 (3.8,6.5) | 0.14 |
| Unknown | 2 | 0 | |
| Heterogeneous histology | 44 (68%) | 18 (72%) | 0.9 |
| Homogeneous: Anastomosing | 6 (9.2%) | 0 | 0.2 |
| Homogeneous: Compact tubular | 11 (17%) | 4 (16%) | >0.9 |
| Homogeneous: Solid | 2 (3.1%) | 2 (8.0%) | 0.3 |
| Homogeneous: Simple tubular | 2 (3.1%) | 1 (4.0%) | >0.9 |
| % Anastomosing (Median, range) | 15 (0,35) | 18 (5,40) | 0.7 |
| % Tubular (Median, range) | 0 (0,20) | 10 (0,20) | 0.10 |
| % Compact (Median, range) | 40 (25,70) | 35 (23,64) | 0.5 |
| % Solid (Median, range) | 10 (0,30) | 8 (0,26) | 0.4 |
| Necrosis (mean % volume) | 3 (0, 0) | 2 (0,11) | 0.6 |
| Necrosis >25% | 7 (11%) | 0 | 0.2 |
| Necrosis (any) | 39 (60%) | 14 (56%) | >0.9 |
| Fibrosis (mean % volume) | 14 (10,20) | 20 (15,26) | 0.009 |
| Geographic-type fibrosis | 9 (14%) | 11 (44%) | 0.005 |
| Low cuboidal cell shape | 58 (89%) | 15 (60%) | 0.005 |
| Plump cuboidal/polygonal shape | 19 (29%) | 15 (60%) | 0.014 |
| Columnar cell shape | 2 (3.1%) | 0 | >0.9 |
| Variable cytoplasm pattern | 19 (29%) | 8 (32%) | >0.9 |
| Intracellular mucin | 8 (12%) | 1 (4.0%) | 0.4 |
| Extracellular mucin | 17 (26%) | 2 (8.0%) | 0.11 |
| Clear cell features | 24 (37%) | 15 (60%) | 0.082 |
| Grade | 0.8 | ||
| 1 | 32 (49%) | 14 (56%) | |
| 2 | 24 (37%) | 9 (36%) | |
| 3 | 9 (14%) | 2 (8.0%) | |
| Perineural invasion | 15 (24%) | 7 (30%) | 0.8 |
| Unknown | 3 | 2 | |
| Lymphovascular invasion | 16 (25%) | 4 (16%) | 0.6 |
| Periductal infiltration | 6 (9.2%) | 2 (8.0%) | >0.9 |
| Satellite nodules | 16 (25%) | 4 (16%) | 0.6 |
| AJCC 8th ed. Primary tumor Stage | 0.5 | ||
| 1 | 24 (37%) | 13 (54%) | |
| 2 | 32 (49%) | 10 (42%) | |
| 3 | 8 (12%) | 1 (4.2%) | |
| 4 | 1 (1.5%) | 0 (0%) | |
| Unknown | 0 | 1 | |
| Regional lymph nodes (at resection) | 0.4 | ||
| pN0 | 22 (34%) | 5 (20%) | |
| pNx | 8 (12%) | 5 (20%) | |
| pNl | 35 (54%) | 15 (60%) |
a
Tumors with neoadjuvant chemotherapy were excluded.