Table 3:

Mutations and Genetic Pathways in IDH1 Mutant and IDH1 Wild Type Small Duct Intrahepatic Cholangiocarcinoma

Variable	Wild type IDH	Mutant IDH1	p-value
	N = 72	N = 29
Gene
ARID1A	18 (25%)	6 (21%)	0.8
BAP1	11 (15%)	7 (25%)	0.3
FGFR2	13 (18%)	0 (0%)	0.017
KRAS	7 (9.7%)	0 (0%)	0.2
PBRM1	14 (19%)	4 (14%)	0.8
TP53	11 (15%)	5 (18%)	0.8
Pathway
SWI/SNFa	32 (44%)	9 (31%)	0.3
DNA damageb	27 (38%)	14 (48%)	0.4
MAPSc	29 (40%)	4 (14%)	0.011
PI3FCd	2 (2.8%)	3 (10%)	0.14

^aSWI/SNF: ARID1A, PBRM1, ATRX

^bDNA Damage: BAP1, TP53, ATM, BRCA1, BARD1, KMT2A, KMT2C

^cMAPK: KRAS, FGFR2, NF1, ARAF, BRAF, RASA1, MAP2K1, MAPK3, PDGFRA, GRIN2A

^dPI3K: PTEN, PIK3R2, RPTOR