Table 3.

Predictors of Overall Survival (OS)

					OS
					Unadjusted HR (95% CI)	p value	Adjusted HR (95% CI)	p value
Covariate	Covariate Grp	Patients	5y OS (%)	10y OS (%)
Age	< 60	252	92	83	Ref	< 0.001	Ref	<0.001
	≥ 60	198	79	52	3.75 (2.59 – 5.45)		3.62 (2.42 – 5.43)
Gender	Male	202	85	62	Ref	0.003	Ref	0.004
	Female	248	88	75	0.59 (0.42 – 0.84)		0.58 (0.40 – 0.84)
Alcohol	No	161	87	70	Ref	0.794
	Yes	272	85	68	1.05 (0.73 – 1.51)
Tobacco	No	214	90	76	Ref	0.027
	Yes	222	82	63	1.50 (1.05 – 2.16)
Comorbidities	No	262	92	77	Ref	< 0.001
	Yes	188	79	59	2.08 (1.48 – 2.94)
Site	Oral Cavity	305	86	74	Ref	0.633	Ref	0.063
	Oropharynx	96	89	59	1.25 (0.84 – 1.88)		0.87 (0.56 – 1.34)
	Sinonasal	38	84	57	1.19 (0.64 – 2.24)		0.56 (0.29 – 1.08)
	Larynx/ Trachea	11	100	80	0.71 (0.18 – 2.89)		0.20 (0.05 – 0.83)
PNI	No	123	93	79	Ref	< 0.001
	Yes	167	80	55	2.76 (1.55 – 4.89)
LVI	No	214	90	71	Ref	0.001
	Yes	53	71	47	2.23 (1.34 – 3.71)
Margin	Negative	214	90	77	Ref	0.015	Ref	0.042
	Close/Positive	229	83	61	1.54 (1.09 – 2.19)		1.56 (1.02 – 2.39)
Pathology risk group	Low	233	93	84	Ref	< 0.001	Ref	0.001
	Intermediate	113	90	60	2.06 (1.31 – 3.22)		1.33 (0.76 – 2.31)
	High	101	68	48	3.72 (2.46 – 5.63)		2.40 (1.51 – 3.82)
pT stage	T1	246	92	82	Ref	< 0.001
	T2	94	82	60	2.24 (1.42 – 3.52)
	T3	20	95	24	4.04 (2.09 – 7.82)
	T4	88	73	53	2.73 (1.79 – 4.16)
pN stage	N0	384	90	75	Ref	< 0.001
	N1	24	62	40	2.64 (1.49 – 4.67)
	N2	41	67	33	4.21 (2.62 – 6.78)
AJCC stage	Stage I	223	94	85	Ref	< 0.001	Ref	< 0.001
	Stage II	74	87	68	1.96 (1.11 – 3.44)		1.60 (0.86 – 2.99)
	Stage III	33	82	35	4.15 (2.24 – 7.24)		6.01 (3.08 – 11.74)
	Stage IV	118	73	49	3.94 (2.61 – 5.97)		3.86 (2.34 – 6.36)
Radiation	No	280	87	77	Ref	0.011	Ref	0.068
	Yes	170	85	56	1.56 (1.10 – 2.19)		0.64 (0.39 – 1.03)

Perineural invasion (PNI), Lymphovascular invasion (LVI), American Joint Cancer Committee (AJCC), Hazard ratio (HR), Reference (Ref)