Table 4.

Predictors of Disease Specific Survival (DSS)

					DSS
Covariate	Covariate Grp	Patients	5y DSS (%)	10y DSS (%)	Unadjusted HR (95% CI)	p value	Adjusted HR (95% CI)	p value
Age	< 60	252	94	85	Ref	0.168
	≥ 60	198	93	75	1.49 (0.84 – 2.61)
Gender	Male	202	92	75	Ref	0.005	Ref	0.021
	Female	248	95	87	0.67 (0.50 – 0.89)		0.49 (0.26 – 0.90)
Alcohol	No	161	96	86	Ref	0.204
	Yes	272	92	79	1.49 (0.80 – 2.79)
Tobacco	No	214	96	87	Ref	0.048
	Yes	222	92	77	1.82 (1.00 – 3.32)
Comorbidities	No	262	95	82	Ref	0.762
	Yes	188	92	82	1.09 (0.61 – 1.95)
Site	Oral Cavity	305	95	89	Ref	0.054	Ref	0.336
	Oropharynx	96	92	71	1.91 (1.01 – 3.62)		1.00 (0.50 – 2.01)
	Sinonasal	38	89	63	2.52 (1.14 – 5.60)		0.64 (0.28 – 1.49)
	Larynx/ Trachea	11	100	80	2.04 (0.48 – 8.62)		0.31 (0.07 – 1.39)
PNI	No	123	98	88	Ref	0.009
	Yes	167	91	71	2.90 (1.25 – 6.71)
LVI	No	214	98	85	Ref	0.001
	Yes	53	79	58	3.24 (1.60 – 6.53)
Margin	Negative	214	96	88	Ref	0.008
	Close/Positive	229	92	74	2.14 (1.20 – 3.83)
Pathology risk group	Low	233	99	97	Ref	< 0.001	Ref	< 0.001
	Intermediate	113	99	70	8.39 (3.15 – 22.35)		2.76 (0.93 – 8.19)
	High	101	77	60	14.69 (5.62 – 38.38)		7.24 (2.57 – 20.44)
pT Stage	T1	246	97	95	Ref	< 0.001
	T2	94	90	73	5.30 (2.23 – 12.30)
	T3	20	100	28	15.20 (5.98 – 38.62)
	T4	88	89	69	7.10 (3.18 – 15.81)
pN stage	N0	384	97	88	Ref	< 0.001
	N1	24	80	48	4.35 (1.91 – 9.93)
	N2	41	77	40	8.07 (4.13 – 15.76)
AJCC stage	Stage I	223	98	98	Ref	< 0.001	Ref	< 0.001
	Stage II	74	95	85	7.58 (1.89 – 30.37)		5.10 (1.20 – 21.74)
	Stage III	33	96	40	32.49 (9.16 – 115.29)		31.26 (7.75 – 126.11)
	Stage IV	118	85	61	26.37 (8.02 – 86.74)		13.46 (3.58 – 50.69)
Radiation	No	280	96	94	Ref	< 0.001	Ref	0.903
	Yes	170	91	65	5.14 (2.68 – 9.84)		0.95 (0.44 – 2.07)