Table 5.

Summary of predictive factors for outcomes in minor salivary tumors: results of multivariate analysis (Statistically significant variables highlighted in grey)

		OS	DSS	RFS	LRFS	RRFS	DRFS
		Adjusted HR (95% CI)	Adjusted HR (95% CI)	Adjusted HR (95% CI)	Adjusted HR (95% CI)	Adjusted HR (95% CI)	Adjusted HR (95% CI)
Covariate	Covariate Grp
Age	< 60	Ref
	≥ 60	3.62 (2.42 – 5.43)
Gender	Male	Ref	Ref
	Female	0.58 (0.40 – 0.84)	0.49 (0.26 – 0.90)
Alcohol	No
	Yes
Tobacco	No
	Yes
Comorbidities	No
	Yes
Site	Oral Cavity	Ref	Ref	Ref	Ref	Ref
	Oropharynx	0.87 (0.56 – 1.34)	1.00 (0.50 – 2.01)	1.59 (0.97 – 2.62)	1.10 (0.44 – 2.76)	1.78 (0.68 – 4.66)
	Sinonasal	0.56 (0.29 – 1.08)	0.64 (0.28 – 1.49)	1.01 (0.56 – 1.82)	1.58 (0.67 – 3.72)	0.46 (0.06 – 3.71)
	Larynx/ Trachea	0.20 (0.05 – 0.83)	0.31 (0.07 – 1.39)	0.75 (0.29 – 1.93)	0.38 (0.05 – 3.00)	-
PNI	No
	Yes
LVI	No
	Yes
Margin	Negative	Ref		Ref	Ref
	Close/Positive	1.56 (1.02 – 2.39)		1.52 (0.91 – 2.52)	1.72 (0.74 – 3.99)
Pathology risk group	Low	Ref	Ref	Ref	Ref	Ref	Ref
	Intermediate	1.33 (0.76 – 2.31)	2.76 (0.93 – 8.19)	3.31 (1.65 – 6.65)	1.51 (0.48 – 4.81)	2.79 (0.72 – 10.81)	8.18 (2.79 – 23.99)
	High	2.40 (1.51 – 3.82)	7.24 (2.57 – 20.44)	4.83 (2.47 – 9.45)	4.78 (1.71 – 13.36)	6.87 (2.19 – 21.50)	8.60 (2.87 – 25.79)
pT stage	T1				Ref
	T2				4.23 (1.27 – 14.12)
	T3				16.27 (3.61 – 73.30)
	T4				9.57 (3.10 – 29.58)
pN stage	N0					Ref
	N1					1.13 (0.14 – 9.25)
	N2					3.09 (0.79 – 12.12)
AJCC stage	Stage I	Ref	Ref	Ref			Ref
	Stage II	1.60 (0.86 – 2.99)	5.10 (1.20 – 21.74)	3.21 (1.43 – 7.22)			3.98 (1.29 – 12.32)
	Stage III	6.01 (3.08 – 11.74)	31.26 (7.75 – 126.11)	7.35 (3.10– 17.41)			11.05 (3.70 – 32.96)
	Stage IV	3.86 (2.34 – 6.36)	13.46 (3.58 – 50.69)	7.11 (3.51 – 14.41)			9.28 (3.52 – 24.44)
Radiation	No	Ref	Ref		Ref	Ref
	Yes	0.64 (0.39 – 1.03)	0.95 (0.44 – 2.07)		0.63 (0.27 – 1.46)	0.64 (0.20 – 2.05)