Table 2.

Experimental endpoints in female mice that differed with those in male mice.¹

	Sham (a)	CIA (b)	ODE (c)	CIA +ODE (d)	Versus male mice3
Arthritis score: Week 1	0.0±0.0	0.2±0.12	0.7±0.12**	0.6±0.19*	c↑, d↑
Arthritis score: Week 3	0.0±0.0	0.4±0.19	0.4±0.19	0.2±0.12	d↓
Arthritis score: Week 4	0.0±0.0	0.5±0.35	0.5±0.22	0.3±0.12	d↓
Arthritis score: Week 5	0.0±0.0	0.5±0.29	0.2±0.2	0.2±0.2	d↓
Bone mineral density2	1.00 ± 0.01	1.03 ± 0.01	0.98 ± 0.02	1.01 ± 0.01	b↑, d↑
Trabecular number2	1.00 ± 0.03	0.78 ± 0.08*	1.05 ± 0.10	0.951± 0.08	d↑
Polar moment of inertia2	1.00 ± 0.04	0.79 ± 0.07*	1.06 ± 0.13	1.05 ± 0.16	d↑
BALF TNF-α (pg/ml)	0.0±0.0	0.6±0.4	15.9±9.9**,#	0.1±0.1	c↓,d↓
BALF IL-6 (pg/ml)	0.3±03	0.4±0.4	213.6±80.0**	101.7±34.0*	c↓,d↓
BALF CXCL1 (pg/ml)	0.1±0.1	155.7±51.4*	274.1±67.4*	139.5±19.0*	c↓
BALF CXCL2 (pg/ml)	0.0±0.0	50.7±12.4**	69.6±23.3**	29.1±5.8**	c↓,d↓
Lung Hyaluronan (ng/ml)	473±6	624±47*	895±113**,^	864±44**,^	a↓,d↓
Lung Fibronectin (ng/ml)	223±27	317±88	277±31	397±21**	c↓,d↓
Lung Amphiregulin (pg/ml)	170±19	12±12*	501±70***,^^	242±36	b↓, d↓
Bronchiolar lung score	0.0±0.0	0.25±0.25	1.25±0.25**	1.0±0.3*	d↓
CCP IgG (ng/ml)	62.5±6.2	347.3±44.53*	30.35±22.19^^	388.4±125.5*	b↑,c↓
Collagen type II ab (μg/ml)	0.05±0.04	6.3±3.3**	0.035±0.019	7.6±0.77**	b↓,d↓
Anti-MAA (Rel units)	110.6±46.3	991±366**	343.5±40.05^	518.5±104.1	b↑,c↑,d↑

¹Statistical difference vs. sham denoted

^*p<0.05

^**p<0.01;

between ODE and CIA+ODE denoted (##p<0.01); vs. CIA denoted

^{^}p<0.05 and

^{^^}p<0.01.

N=5 female mice/group.

²Data represent the difference induced by treatments divided by sham of proximal tibia.

³Statistical differences between females vs. males of same exposure denoted with letter when p<0.05 for sham (a), CIA (b), ODE (c), and CIA+ODE (d) groups and arrow represents direction of difference of female findings as compared to males.