Table 1.

The 5-tier ENIGMA classification of variants based on the ranges in the probability of pathogenicity (PoP).

Class	1. Benign	2. Likely Benign	3. Uncertain	4. Likely Pathogenic	5. Pathogenic
PoP range	<0.001	0.001–0.049	0.05–0.949	0.95–0.99	>0.99