Table 7.

Pathogenicity-prediction performance comparison (2-class evaluations) among MLR (multi-class logistic regression), CLM (cumulative logit model), and our WSR (weakly supervised regression) variants.

	ClinVar Test Set		CAGI Test Set
Model	Binary AUC	RMSD	Binary AUC	RMSD
MLR	0.751 ± 0.004	0.251 ± 0.005	0.720 ± 0.011	0.277 ± 0.003
CLM	0.853 ± 0.006	0.220 ± 0.004	0.854 ± 0.008	0.213 ± 0.005
WSR1	0.801 ± 0.010	0.212 ± 0.012	0.780 ± 0.005	0.234 ± 0.010
WSR2	0.971 ± 0.001	0.201 ± 0.004	0.961 ± 0.003	0.198 ± 0.004
WSR3 (Kernelized WSR2)	0.982 ± 0.003	0.131 ± 0.004	0.968 ± 0.002	0.161 ± 0.003