Table 8.

Summarized results of WSR2 model interpretation for 16 pathogenic and likely pathogenic BRCA variants. Important features are retained with a P-value cutoff of 1E-02 and ranked from left to right in increasing P-values. PoP predictions of WSR3, more accurate yet less interpretable, are also reported. Bold-faced are correctly predicted (likely) pathogenic.

	Variants	WSR2		WSR3
		Predicted PoP	Indices of important features	Predicted PoP
Class 5	BRCA1 (NP_009225.1)
	p.M18T	0.988 ± 0.003	2 5 6 9 8 7	0.953 ± 0.004
	p.C44F	0.981 ± 0.002	8 7 2 6 5 9 1	0.957 ± 0.010
	p.C47Y	0.953 ± 0.015	8 2 7 6 5	0.956 ± 0.004
	p.R71G	0.803 ± 0.002	7 4 2 5 9	0.050 ± 0.002
	p.R1495T	0.501 ± 0.020	1 5 2	0.990 ± 0.008
	p.E1559K	0.501 ± 0.016	5 7 1	0.990 ± 0.009
	p.S1715N	0.959 ± 0.003	5 2 6 9 7 4	0.953 ± 0.007
	BRCA2 (NP_000050.2)
	p.R2659G	0.981 ± 0.004	3 2 4 5 8 9	0.960 ± 0.005
	p.Q2829R	0.697 ± 0.009	6 5 2 7 9	0.953 ± 0.009
	p.N3124I	0.964 ± 0.005	3 2 6 9 4 5 7	0.953 ± 0.004
Class 4	BRCA1 (NP_009225.1)
	p.V1736G	0.565 ± 0.002	2 8 3 7 6	0.953 ± 0.009
	p.G1738E	0.991 ± 0.001	2 8 3 7 6 5	0.952 ± 0.007
	p.D1739V	0.996 ± 0.001	3 2 8 6 4	0.963 ± 0.008
	p.G1748D	0.996 ± 0.004	3 2 8 7 6 4	0.952 ± 0.001
	BRCA2 (NP_000050.2)
	p.T2607P	0.681 ± 0.006	6 5 9 2 4	0.820 ± 0.010
	p.S2670L	0.501 ± 0.004	2 7	0.954 ± 0.009