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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Hum Mutat. 2019 Jul 3;40(9):1593–1611. doi: 10.1002/humu.23802

Table 2.

Composition of the ENIGMA dataset in the CAGI 5 challenge

 (A) BRCA1
IARC 5-tier
class 		1
(<0.001)		 2
(0.001–0.049)		 3
(0.05–0.949)		 4
(0.95–0.99)		 5
(>0.99)
CAGI 31 100 2 4 7
Three Class† Neutral Unknown Pathogenic
CAGI 131 2 11
(B) BRCA2
IARC 5-tier
class 		1
(<0.001)		 2
(0.001–0.049)		 3
(0.05–0.949)		 4
(0.95–0.99)		 5
(>0.99)
CAGI 31 136 2 2 3
Three Class† Neutral Unknown Pathogenic
CAGI 167 2 5
†

This classification is a simplified version of the IARC 5-tier scheme (see manuscript) where the Neutral class corresponds to IARC classes 1 and 2, the Pathogenic class corresponds to IARC classes 4 and 5, and Unknown corresponds to IARC class 3.