Table 1:

Summary of data set pre-processing and the resulting variant numbers

Data set	#variants (PTEN)	#variants (TPMT)	#variants (Total)	Range of exp. values [min, max]
Original data set	4,000	3,952	7,952	[−0.975, 2.198]
Nonsense	120	196	316	[−0.975, 2.198]
Negative score	20	143	163	[−0.975, 0.000]
Final data set	3,860	3,613	7,473	[0.001, 2.198]
Effect	2,448	1,853	4,301	[0.001, 2.198]
Stabilizing	852	787	1,639	[0.841, 2.198]
Destabilizing	1,596	1,066	2,662	[0.001, 1.338]
Wild-Type	539	698	1,237	[0.900, 1.099]
Synonymous	144	129	273	[0.130, 2.010]
Classification data set	2,987	2,551	5,538	[0.001, 2.198]