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. 2019 Sep 13;9:13259. doi: 10.1038/s41598-019-49853-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FAK inhibition diminished progression through the cell cycle. (A) COA3 cells (3 × 10⁶) were treated with increasing doses of PF (0, 5, 20 μM) or Y15 (0, 5, 10 μM) for 72 hours. Cells were stained with propidium iodide and cell cycle was analyzed via flow cytometry. FAK inhibition led to an increase in percentage of cells in the G1 phase and a decrease in percentage of cells in S phase. This change was statistically significant and represents failure to progress through the cell cycle. (B) COA6 cells (3 × 10⁶) were treated with increasing doses of PF (0, 5, 20 μM) or Y15 (0, 5, 10 μM) for 72 hours. Cells were stained with propidium iodide and cell cycle was analyzed via flow cytometry. FAK inhibition led to an increase in percentage of cells in the G1 phase and a decrease in percentage of cells in S phase. This change was also statistically significant, representing failure to progress through the cell cycle. (C) Cell cycle data are presented in tabular form. Data represent at least three biologic replicates and are reported as mean ± SEM.