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. 2019 Sep 13;9:13249. doi: 10.1038/s41598-019-49550-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ALKBH expression in HNSCC and indicated cell lines: (A) WB analysis of ALKBH expression in HNSCC samples. siRNA - HeLa cells treated with siRNAs directed towards particular ALKBHs; Cont. - HeLa cells not treated by siRNA; Nor - normal periphery; Can- cancer; A-F - tumour samples. (B) WB analysis of ALKBH expression in various cell lines: normal, cancer and embryonic. (C) ALKBHs expression in cancer and normal tissues from HNSCC patients. Samples were classified into three groups according to the expression level of each protein: (i) stronger signal from cancer than normal surrounding; (ii) weaker signal from cancer than normal surrounding; (iii) no detectable expression of the proteins in the normal and cancer tissue. N – number of patients; p - p-value obtained from the Wilcoxon signed-rank test for paired samples. (D) Nonparametric Wilcoxon rank-sum test (for groups) were performed. n- number of samples from each group; P-values with Benjamini-Hochberg adjustment: *p < 0.025; **p < 0.005; ***p < 0.0005; ****p < 0.00005; *****p < 0.000005. (E) Heat map of changes of individual protein expression in HNSCC. Fold changes were calculated for tumour vs. adjacent normal tissue. White - no detectable expression of particular protein in cancer and adjacent tissue. Blue - decreased relative protein level. Orange - increased relative protein level. Grey - no data gathered.