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. 2019 Sep 13;9:13249. doi: 10.1038/s41598-019-49550-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationships between protein levels within ALKBH family members. (A) Relationship between the levels of ALKBH proteins in healthy surrounding tissue and (B) HNSCC tumour. Each tabulated entry presents the Spearman’s rank correlation coefficient and indicates the p-value of correlation. Hierarchical cluster analysis of matrices presents similarities between examined ALKBHs. P-values with Benjamini-Hochberg adjustment: ‘p < 0.005; *p < 0.0025; **p < 0.0005; ***p < 0.00005; ****p < 0.000005. (C) Impact of individual ALKBH protein silencing on expression of its homologs in HeLa. Silencing was done with the use of small interfering RNA, ALKBH protein levels were measured by WB.