Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 13;9:13249. doi: 10.1038/s41598-019-49550-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Design and in vitro examination of ALKBHs inhibitors. (A) Results of in silico screening for the binding of anthraquinone derivatives by ALKBH proteins. Molecular docking indicated that FTO and EcAlkB are the best targets, followed by ALKBH2 and ALKBH3, albeit each of these proteins displayed specificity towards particular ligands. Other ALKBH proteins virtually did not bind any of the ligands tested. (B,C) The results of the thermal shift assay for ALKBH3 and FTO in the presence of tested anthraquinones. ΔH - enthalpy, T_m - protein melting temperature. (D) Inhibitory effect of anthraquinones on EcAlkB protein and its human homologs.