Table 1.
Demographics of probands and tested FDRs
| Variable | Probands (N = 183) | FDRs (N = 112) |
|---|---|---|
| Age | ||
| Mean (CI) | 45.7 (43.6–47.9) | 38.9 (35.7–42.11) |
| Sex | ||
| Male (%) | 33 (18.0) | 41 (36.6) |
| Female (%) | 150 (82.0) | 71 (63.4) |
| Race | ||
| Chinese (%) | 136 (74.3) | 80 (71.4) |
| Malay (%) | 28 (15.3) | 20 (17.8) |
| Indian (%) | 11 (6.0) | 6 (5.4) |
| Others (%) | 8 (4.4) | 6 (5.4) |
| Phenotype a | ||
| Symptomatic (%) | 180 (98.4) | 22 (19.6) |
| Asymptomatic (%) | 3 (1.6) | 90 (80.4) |
| Gene cohort b | ||
| Tier 1 (%) | 104 (56.8) | 56 (50.0) |
| Syndromic (%) | 55 (30.1) | 47 (42.0) |
| Emerging evidence (%) | 24 (13.1) | 9 (8.0) |
| LKCNCCS subsidy | ||
| Eligible (%) | 65 (35.5) | 23 (20.5) |
| Not eligible (%) | 118 (64.5) | 89 (79.5) |
| Genetic result | ||
| PV/LPV detected (%) | 183 (100.0) | 53 (47.3) |
| PV/LPV not detected (%) | 0 (0.0) | 59 (52.7) |
CI confidence interval (95%), FDR first-degree relative, LKCNCCS Lee Kong Chian National Cancer Centre Singapore Cancer Genetics Service fund, PV/LPV pathogenic variant/likely pathogenic variant
aPhenotype associated with familial PV/LPV present (symptomatic) or absent (asymptomatic) at time of testing
bSee Supplementary Table 1 for genes included in each cohort