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. 2019 Sep 13;9:13210. doi: 10.1038/s41598-019-49748-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The analyses of correlations among the percentages of different Breg subsets, plasma cytokine levels, and SLE clinical parameters in newly diagnosed SLE patients. (A,B) The correlation between the percentage of circulating IL-35⁺ Bregs and the SLEDAI score (A) or ESR level (B). (C,D) The correlation between the percentage of circulating IL-10⁺ Bregs and the SLEDAI score (C) or ESR level (D). (E,F) The correlation between the plasma IL-35 level and the SLEDAI score (E) or ESR level (F). (G) The correlation between the percentage of circulating CD5⁺ Bregs and the plasma IgA level. (E,F) The correlation between the plasma IL-10 level and the plasma C4 (E) or CRP (F) level. SLEDAI, SLE disease activity index; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein. All P values < 0.05, as determined by the Spearman’s rank correlation test.