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. 2019 Sep 13;10:4189. doi: 10.1038/s41467-019-12007-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Integration-promoted DNA sliding observed by cryo-EM. a On the left, slabbed view of the isolated D02 NCP. Histone H3 L1 element is highlighted with a blue ball. On the right, DNA looping required for retroviral integration causes a shift in the DNA register, which extends from SHL 7 to 2. Histone H3 L1 element prevents downstream DNA sliding. b Schematic representation of integration-induced NCP remodelling