Table 1.
Overview of secondary parameter conversions into pump setting for selected hollow fiber experiments.
| Parameter | Isoniazid | Isoniazid -rifampicin | Isoniazid -pyrazinamide |
|---|---|---|---|
| CMAX isoniazid (ng/ml)* | 1,200 | 1,200 | 1,200 |
| CMAX companion drug (ng/ml)* | — | 400 | 28,900 |
| TMAX (hour) | 2.15 | 2.15 | 2.15 |
| T1/2 isoniazid (hour) | 4.7 | 4.7 | 4.7 |
| T1/2 companion drug (hour) | — | 4.7 | 8.02 |
| Flow rate dilution/serial top-up/elimination reservoir (ml/min) | 0.18 | 0.18 | 0.18 |
| Flow rate dilution/serial top-up/elimination reservoir start time (min) | 129 | 129 | 129 |
| Amount isoniazid (ug) | 90 | 90 | 90 |
| Amount companion drug (ug) | — | 30 | 2,168 |
| Syringe infusion rate isoniazid (ug/min) | 0.70 | 0.70 | 0.70 |
| Syringe infusion rate companion drug (ug/min) | — | 0.23 | 16.8 |
| Amount companion drug serial top-up reservoir (ug) | — | — | 4,247 |
| Dilution/serial top-up reservoir (ml) | 265 | 265 | 265 |
*Accounted for protein binding.