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. 2019 Sep 13;10:4179. doi: 10.1038/s41467-019-12081-0

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© The Author(s) 2019, corrected publication 2022

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Fig. 4 — Genome wide DNA methylation analysis in skeletal muscle. The number of differentially methylated CpG sites between the indicated groups (a). A total of 2956 CpG sites are located in/or in close proximity of 921 genes exhibiting different expression between baseline and 52 weeks. Gene ontology analysis of 921 differentially expressed genes with altered levels of DNA methylation at 52 weeks (b). Up- and downregulated genes are indicated by red and blue signals, respectively. *p < 0.05 (unadjusted p-value paired t test for gene expression, n = 16, methylation data with Benjamini Hochberg correction)