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. 2019 Sep 13;9:13261. doi: 10.1038/s41598-019-49860-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutational profile of therapy naive cholangiocarcinoma patients assessed by targeted resequencing analysis of tumor tissue and ctDNA and concordance of mutations detected in tumor tissue and ctDNA of therapy naive cholangiocarcinoma patients. (A) Proportion of patients with identical mutational profile in tumor tissue and ctDNA. Data are shown for the entire cohort (top) and grouped by tumor localization, for IHCCs (middle) and for EHCCs only (bottom). (B) Detailed mutational profile per patient. Patients were sorted by mutation frequency per gene and separated according to primary tumor localization. Only genes with detected mutations are shown here. (C) Number of total unique variants identified per gene. No statistical difference in the mean number of unique variants between tumor and ctDNA (P = 0.3125, Wilcoxon) or between IHCC and EHCC patients (tumor p > 0.9999, Wilcoxon; ctDNA P = 0.3594, Wilcoxon). (D) Venn diagram showing the overlap between ctDNA and tumor biopsy sequencing analysis for every mutation reported. IHCC - intrahepatic cholangiocarcinoma; EHCC - extrahepatic cholangiocarcinoma.