Table 1.

Fitted kinetic parameters. CL, CLd, V1 and V2 are standard pharmacokinetic parameters representing systemic clearance, distribution clearance, central distribution volume and peripheral distribution volume, respectively. While k1 and k2 represent nonspecific distribution kinetics within tumor, k3 and k4 represent approximately linear target-specific kinetics, e.g., binding/dissociation, as described by Innis et al. [29]

	CL (ml/min)	CLd (ml/min)	V1 (ml)	V2 (ml)	k1 (1/min)	k2 (1/min)	k3 (1/min)	k4 (1/min)	k_heart (1/min)
VCAM-MPIO	0.06 ± 0.03	5.0 ± 2.7	5.1 ± 1.5	4.9 ± 1.7	1.7 ± 2.2	185 ± 236	18.1 ± 15.3	1.8 ± 2.1	1.8 ± 0.6
IgG-MPIO	0.06 ± 0.03	2.9 ± 0.9	2.7 ± 0.4	11.6 ± 0.4	0.2 ± 0.1	14 ± 10	0.05 ± 0.004	0.01 ± 0.002	1.4 ± 0. 3