Table 1.
Demographic and clinical characteristics: preoperative RAS inhibitors
| Unadjusted | Inverse probability weighted adjusted | Matched data | |||||||
|---|---|---|---|---|---|---|---|---|---|
| PreRASi (n = 3603) | No-PreRASiI (n = 4978) | p-value | PreRASi (n = 3603) | No-PreRASi (n = 4978) | p-value | PreRASi (n = 3284) | No-PreRASi (n = 3284) | p-value | |
| Age | 65.9 ± 11.7 | 64.8 ± 13.6 | <0.0001 | 65.6 ± 18.9 | 65.3 ± 17.2 | 0.34 | 65.9 ± 11.8 | 66.0 ± 12.4 | 0.70 |
| Male | 68.9 | 67.4 | 0.14 | 68.2 | 68.0 | 0.83 | 68.4 | 68.7 | 0.83 |
| BMI | 29.2 ± 6.2 | 28.6 ± 6.2 | <0.0001 | 28.9 ± 9.5 | 28.9 ± 8.3 | 0.74 | 29.1 ± 6.1 | 29.1 ± 6.3 | 0.88 |
| Diabetes | 38.7 | 27.6 | <0.0001 | 32.9 | 32.5 | 0.60 | 35.8 | 35.2 | 0.66 |
| Smoker | 40.7 | 39.5 | 0.26 | 40.3 | 40.1 | 0.72 | 40.2 | 40.4 | 0.92 |
| Hypertension | 87.3 | 69.9 | <0.0001 | 78.4 | 77.4 | 0.14 | 86.2 | 87.0 | 0.35 |
| Cerebrovascular disease | 18.1 | 15.4 | 0.001 | 16.8 | 16.7 | 0.83 | 17.5 | 17.1 | 0.70 |
| Peripheral arterial disease | 13.9 | 11.6 | 0.002 | 12.7 | 12.6 | 0.91 | 13.4 | 12.8 | 0.49 |
| Chronic lung disease | 18.8 | 20.1 | 0.04 | 20.3 | 19.8 | 0.49 | 19.6 | 19.7 | 0.90 |
| Family history CAD | 40.5 | 38.3 | 0.04 | 39.7 | 39.3 | 0.58 | 40.6 | 41.3 | 0.58 |
| Angina | 37.2 | 34.6 | 0.02 | 36.1 | 35.9 | 0.73 | 37.8 | 38.3 | 0.51 |
| Congestive heart failure | 32.7 | 28.6 | <0.0001 | 31.4 | 30.7 | 0.30 | 30.7 | 30.5 | 0.89 |
| Previous MI | 36.4 | 30.2 | <0.0001 | 33.5 | 33.0 | 0.47 | 35.0 | 35.1 | 0.94 |
| Beta blockers | 72.6 | 63.3 | <0.0001 | 68.9 | 67.6 | 0.09 | 71.4 | 71.5 | 0.87 |
| Aspirin | 75.9 | 66.6 | <0.0001 | 71.3 | 70.7 | 0.34 | 74.5 | 74.5 | 0.98 |
| Lipid lowering | 82.2 | 74.1 | <0.0001 | 78.3 | 77.7 | 0.35 | 81.1 | 81.5 | 0.73 |
| Urgent | 49.9 | 52.9 | 0.01 | 51.7 | 51.6 | 0.86 | 51.1 | 51.9 | 0.52 |
| CABG | 49.5 | 51.9 | <0.0001 | 55.3 | 55.0 | 0.76 | 58.3 | 58.5 | 0.84 |
| Valve | 24.0 | 29.3 | <0.0001 | 27.0 | 27.1 | 0.90 | 24.8 | 24.9 | 0.93 |
| Post RAS inhibitor | 46.0 | 25.6 | <0.0001 | 45.8 | 26.7 | <0.0001 | 46.0 | 28.5 | <0.0001 |
| Cardiopulmonary bypass time | 130.7 ± 80.5 | 126.3 ± 79.6 | 0.012 | 128.2 ± 121.1 | 128.3 ± 107.0 | 0.96 | 127.5 ± 77.8 | 126.3 ± 79.7 | 0.52 |
| Cross clamp time | 93.8 ± 59.5 | 90.8 ± 58.9 | 0.020 | 92.3 ± 90.2 | 92.2 ± 79.3 | 0.97 | 91.8 ± 58.1 | 90.9 ± 58.9 | 0.53 |
| Number of artery grafts | 0.012 | 0.80 | 0.14 | ||||||
| None | 45.7 | 48.8 | 46.7 | 47.2 | 46.2 | 48.2 | |||
| 1 | 45.5 | 42.4 | 44.4 | 44.0 | 45.3 | 42.8 | |||
| 2 or more | 8.8 | 8.8 | 8.9 | 8.8 | 8.5 | 8.9 | |||
| On-off pump | 0.0021 | 0.80 | 0.39 | ||||||
| Off pump | 6.5 | 6.7 | 6.4 | 6.5 | 6.7 | 6.2 | |||
| On pump (full) | 93.5 | 93.3 | 93.6 | 93.5 | 93.3 | 93.8 | |||
Values are mean ± SD or %. C-index = 0.74. p-values are obtained via analyses using Pearson chi-square test or Wilcoxon rank-sum test (unadjusted) and then IPW or PSM (adjusted)
BMI body mass index, MI myocardial infarction