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. 2019 Sep 13;9:13254. doi: 10.1038/s41598-019-49684-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alterations in the repertoire of protein-bound epidermal lipids in Fatp4^−/− mice. Protein-bound lipids from newborn mouse epidermis were co-resolved by TLC with standards and free epidermal lipids (a) and quantified in µg per mg of dry epidermis (b). The decreased levels of OHFA and Cer(OS) seen in Fatp4^−/− mice were normalized by the Fatp1 (Fatp4^−/−; Tg(IVL-Fatp1) in a, left; b, left) and Fatp4 (Fatp4^−/−; Tg(IVL-Fatp4) in a, right; b, right) transgenes. A faster migrating FA band was seen in some Fatp4^−/− samples. Lipid standards (a, left) and protein-bound epidermal lipids (arrows) are indicated. Quantification data (b) were obtained from two separate studies with standard deviation and statistical significance indicated (**P < 0.01; ***P < 0.001). Each study contained 6 each of control, Fatp4^−/−, and transgene-rescued mutant mice. The TLC results shown in a are from two separate TLC experiments; full vertical lengths are shown. IVL, involucrin promoter.

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