Figure 2. Relationship between dose-adjusted and dose/kg-adjusted cyclosporine A concentrations and metabolic ratios of cyclosporine A metabolites AM1, AM9, AM4N, dMC-CsA, dihydroxylated-CsA and trihydroxylated-CsA.

(A and B) Lack of correlations between cyclosporine C/D and C/D/kg and metabolic ratios of AM1, AM9, AM4N, DiH-CsA, TriH-CsA, dMC-CsA and AM1+AM9+AM4N. CsA, cyclosporine A; ISD, immunosuppressive drug; AM1, 1-hydroxy cyclosporine; AM9, 9-hydroxy cyclosporine; AM4N, 4-N-demethyl cyclosporine; dMC-CsA, demethylcarboxylated cyclosporine metabolites; DiH-CsA, dihydroxylated cyclosporine metabolites; TriH-CsA, trihydroxylated cyclosporine metabolites; KTX, kidney transplant.