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. 2019 Sep 3;6:100036. doi: 10.1016/j.ynpai.2019.100036

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© 2019 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 6 — Overview of a healthy, naïve knee joint (A), in comparison to a MIA-injected, osteoarthritic knee joint (B). Figures A1 and A2 show healthy chondrocytes forming a triangular meniscus (A1: HE staining; A2: Safranin-O staining). Necrotic chondrocytes and loss of shape was observed in the meniscus after MIA injection (B1: HE staining) accompanied with loss of proteoglycan shown in Safranin-O staining (B2). The femoropatellar articulate surface in naïve joint is shown in figures A3 (HE staining) and A4 (Safranin-O-staining). Degenerative, diffuse, chronic erosive changes were seen in MIA-injected joints (B3: HE staining), confirmed with Safranin-O staining in B4. A5 (HE staining) shows the healthy subpatellar fat pad in comparison to the replacement of the fad pad with connective tissue overlined by synovial hypertrophy in MIA-injected joints (B5). Normal synovial epithelium in naïve rat is shown in A6, compared to the synovial hypertrophy and sub-synovial granulation tissue accumulation observed in the MIA-injected knee joint (B6).