Fig. 9.

Summary of CL-induced microbiota composition changes and its impact on host susceptibility to V. cholerae infection. A remarkable shift in commensal microbiota population occurs in response to treatment with CL. Under normal condition, B. vulgatus, and to a lesser degree, also Clostridium spp. metabolize mucin glycan and accumulation of metabolites including SCFAs that suppress V. cholerae intestinal growth ensues. Metabolites that increased in quantities upon CL treatment, such as amino sugars, potentiate V. cholerae intestinal growth