Table 2.
Collagen as a prognostic factor for cancer patients
| Subtype | Condition | Cancer | Associated clinical significance | References |
|---|---|---|---|---|
| COLI | Intactness | Colorectal cancer | Changes dynamically at stages I to IV, peaking at stage II | [249] |
| Intactness | Prostate cancer | Metastasis | [250] | |
| COL1A1 | Breast cancer | Development and progression along with COL3A1 and COL4A1 | [251] | |
| COL1A2 | Colorectal cancer | Proliferation, migration, and invasion | [252] | |
| COL1A2 | Hepatocellular cancer | Metastasis | [253] | |
| N-terminal telopeptide | NSCLC | Overall survival | [254] | |
| N-terminal telopeptide | Head and neck SCC | Overall survival along with N-terminal telopeptide of COLIII | [255] | |
| Pyridinoline crosslinked C-terminal telopeptide (serum) | Breast cancer | Recurrence | [256] | |
| N-terminal telopeptide (urine) | Breast cancer with bone metastases | Survival prognosis with zoledronic acid treatment for 3 months | [257] | |
| COLII | COL2A1 | High-grade serous ovarian cancer | Recurrence | [258] |
| COL2A1 | Chondrosarcoma | Frequent mutations | [259] | |
| COLIII | COL3A1 | Breast cancer | Irregular margin status and mitotic activity | [260] |
| COLIV | Intactness | Advanced gastric carcinoma | The depth of wall penetration and stage | [261] |
| Intactness | Oral SCC | Positive lymph node status | [262] | |
| Intactness | Colorectal cancer | Liver metastases | [263] | |
| 7S domain (serum) | Hepatocellular carcinoma | Intractable ascites | [264] | |
| COL4A1 | PDAC | Aggressive progression | [265] | |
| COL4A1 (urine) | Bladder cancer | Recurrence | [266] | |
| COL4A3 | Gastric carcinomas | Cancer size, lymphatic invasion, venous invasion, TNM stage, and histologically distinction | [267] | |
| COLV | Intactness | Resected NSCLC | Overall survival | [268]. |
| COLVI | COL6A1 | Cervical cancer | Overall and recurrent-free survival | [269] |
| COLXI | COL11A1 | Esophageal SCC | Advanced clinical stage and lymph node metastases | [270] |
| COLXIII | COL13A1 (urine) | Bladder cancer | Recurrence | [266] |
| COLXVII | Intactness | Colorectal cancer | Invasion and metastasis | [271] |
| Intactness | SCC | Invasion | [272] | |
| Intactness | Colon cancer | Metastasis | [273] | |
| COLXXIII | Intactness (tissue and urine) | NSCLC | Recurrence | [274] |