Fig. 5.

Bacterial community state types over time in patients undergoing allogeneic HSCT. Patients are grouped into four outcome groups: (1) patients who developed no or mild aGvHD (grade 0–I) and survived vs. (2) patients who did not survive; (3) patients who developed moderate to severe aGvHD (grade II–IV) and survived vs. (4) patients who did not survive. The day of commencement of aGVHD grade II–IV and the day of death post-HSCT are displayed to the right. Patients with moderate to severe aGvHD (groups 3 and 4) most often harbored the Lactobacillaceae-dominated community state type 1 (CST 1), especially at late time points. CST2, dominated by Ruminococcaceae and Lachnospiraceae, did not persist after HSCT in any of the patients in groups 3 and 4. A detailed overview of the CSTs is provided in Additional file 7: Figure S4, and information about individual OTUs and their cluster-affiliation is provided in Additional file 5: Table S3