Table 2.
Mouse elements yielded by a variant of the procedure that exploits only information derived from H and P
| Sequence set of origin | mm10 coordinates | PSWMs with at least a significant hit (first round) | PSWMs with at least a significant hit (second round) | Notes |
|---|---|---|---|---|
| EPO/mouse MOE 1 Mb threshold | chr19:14694517–14,694,929 | 1, 4, 6, 8 | 1, 3, 4, 6, 8 | Predicted enhancer in close proximity |
| EPO/mouse MOE 1 Mb threshold | chr14:49188564–49,189,030 | 1, 4, 6, 8 | 1, 2, 4, 5, 6, 8 | On a retained intron |
| EPO/mouse MOE 1 Mb threshold | chr11:107760321–107,760,529 | 1, 8 | 1, 4, 6, 8 | – |
| EPO/mouse MOE 1 Mb threshold | chr7:100639235–100,639,627 | 1 | 1, 5, 8 | – |
| GERP/mouse MOE 1 Mb threshold | chr6:42869807–42,870,110 | 1, 2, 4, 5 | 1, 2, 4, 5, 6, 8 | Overlaps with Sfaktiria |
| GERP/mouse MOE 1 Mb threshold | chr6:42869789–42,870,106 | 1, 2, 4, 5 | 1, 2, 4, 5, 6, 8 | Overlaps with Sfaktiria |
Sets of evolutionarily conserved mouse sequences found within olfactory loci were screened for occurrences of position-specific weight matrices (PSWMs) obtained from multi-aligments of H and P-related sequences (no other known elements being included). Such sets were obtained intersecting the mouse MOE 1 Mb threshold list with mouse Ensembl tracks as either “36 eutherian mammals EPO low coverage” (EPO/mouse MOE 1 Mb threshold) or “GERP constrained elements” (GERP/mouse MOE 1 Mb threshold)