. Author manuscript; available in PMC: 2019 Sep 14.

Published in final edited form as: J Thromb Thrombolysis. 2017 Aug;44(2):145–153. doi: 10.1007/s11239-017-1516-y

Table 3:

Change of Biomarkers over each Time Period by Treatment Group

Table 3a. Baseline to 1 Month by Treatments
Characteristic	Overall Levels at 1 Month	Change in Biomarker Level
Characteristic	Overall Levels at 1 Month	Overall	Clopidogrel	Ticagrelor	p-value
Platelet (x10E⁹/L) N: Median (25th-75th)	5963: 239.0 (200.0 – 288.0)	5963: 6.0 (−21.0–35.0)	2985: 1.0 (−23.0–31.0)	2978: 10.0 (−16.0–39.0)	<.0001
CD40 (ug/L) N: Median (25th-75th)	1897: 0.35 (0.14 – 0.72)	1897: −0.04 (−0.27–0.13)	973: −0.03 (−0.26–0.14)	924: −0.04 (−0.30–0.12)	0.5852
P-Selectin (ug/L) N: Median (25th-75th)	1898: 29.1 (22.5 – 37.3)	1898: −4.4 (−13.0–3.7)	974: −4.3 (−13.6–3.1)	924: −4.4 (−12.6–4.2)	0.2719

Table 3b. 1 Month to 6 Month by Treatments
Characteristic	Overall Levels at 6 Months	Change in Biomarker Level
Characteristic	Overall Levels at 6 Months	Overall	Clopidogrel	Ticagrelor	p-value
Platelet (x10E⁹/L) N: Median (25th-75th)	5963: 237.0 (201.0 – 278.0)	5963: −1.0 (−27.0–22.0)	2985: 0.0 (−26.0–21.0)	2978: −1.0 (−28.0–22.0)	0.9115
CD40 (ug/L) N: Median (25th-75th)	1897: 0.31 (0.12 – 0.74)	1897: −0.01 (−0.22–0.17)	973: −0.02 (−0.24–0.19)	924: −0.01 (−0.20–0.17)	0.7871
P-Selectin (ug/L) N: Median (25th-75th)	1898: 30.1 (23.1 – 39.3)	1898: 1.3 (−5.8–8.4)	974: 1.5 (−5.5–8.4)	924: 1.2 (−6.1–8.4)	0.4223