Table 5:
Changes in Platelet-Related Biomarkers and Their Association with Clinical Outcomes from Cox proportional hazards models
| Outcome | Biomarker changes | Hazard Ratio | 95% Lower Confidence Limit for Hazard Ratio | 95% Upper Confidence Limit for Hazard Ratio | P Value |
|---|---|---|---|---|---|
| CVD/MI/Stk | Platelet:change per 100 from BL to 1M | 1.195 | 0.846 | 1.687 | 0.3119 |
| Platelet:change per 100 from 1m to 6 M | 1.512 | 1.094 | 2.090 | 0.0122 | |
| CD40:change from BL to 1 M | 0.914 | 0.591 | 1.414 | 0.6865 | |
| CD40:change from 1m to 6 M | 1.128 | 0.967 | 1.317 | 0.1252 | |
| Selectin:change per 100 from BL to 1M | 0.106 | 0.009 | 1.297 | 0.0789 | |
| Selectin:change per 100 from 1m to 6 M | 0.494 | 0.077 | 3.181 | 0.4576 | |
| CV Death | Platelet:change per 100 from BL to 1M | 1.265 | 0.804 | 1.989 | 0.3090 |
| Platelet:change per 100 from 1M to 6M | 1.972 | 1.323 | 2.939 | 0.0008 | |
| CD40:change from BL to 1M | 0.683 | 0.343 | 1.359 | 0.2768 | |
| CD40:change from 1M to 6M | 1.180 | 0.946 | 1.472 | 0.1425 | |
| Selectin:change per 100 from BL to 1M | 0.020 | 0.000 | 1.523 | 0.0768 | |
| Selectin:change per 100 from 1M to 6M | 0.226 | 0.009 | 5.873 | 0.3709 | |
| All Cause Death | Platelet:change per 100 from BL to 1M | 1.373 | 0.912 | 2.068 | 0.1287 |
| Platelet:change per 100 from 1M to 6M | 2.232 | 1.547 | 3.219 | <.0001 | |
| CD40:change from BL to 1M | 0.683 | 0.343 | 1.359 | 0.2768 | |
| CD40:change from 1M to 6M | 1.180 | 0.946 | 1.472 | 0.1425 | |
| Selectin:change per 100 from BL to 1M | 0.020 | 0.000 | 1.523 | 0.0768 | |
| Selectin:change per 100 from 1 M to 6M | 0.226 | 0.009 | 5.873 | 0.3709 | |
| MI | Platelet:change per 100 from BL to 1M | 1.247 | 0.778 | 1.999 | 0.3581 |
| Platelet:change per 100 from 1 M to 6M | 1.537 | 0.980 | 2.412 | 0.0612 | |
| CD40:change from BL to 1M | 1.155 | 0.852 | 1.566 | 0.3541 | |
| CD40:change from 1M to 6M | 1.126 | 0.889 | 1.427 | 0.3256 | |
| Selectin:change per 100 from BL to 1M | 1.519 | 0.111 | 20.798 | 0.7541 | |
| Selectin:change per 100 from 1M to 6M | 1.337 | 0.205 | 8.700 | 0.7614 | |
| Major Bleeding | Platelet:change per 100 from BL to 1M | 1.390 | 0.882 | 2.188 | 0.1556 |
| Platelet:change per 100 from 1M to 6M | 1.661 | 1.047 | 2.634 | 0.0312 | |
| CD40:change from BL to 1M | 0.929 | 0.481 | 1.794 | 0.8269 | |
| CD40:change from 1M to 6M | 1.396 | 1.174 | 1.660 | 0.0002 | |
| Selectin:change per 100 from BL to 1M | 0.583 | 0.031 | 10.907 | 0.7183 | |
| Selectin:change per 100 from 1M to 6M | 1.236 | 0.193 | 7.927 | 0.8230 | |
| Non-CABG Major Bleeding | Platelet:change per 100 from BL to 1M | 2.224 | 1.357 | 3.645 | 0.0015 |
| Platelet:change per 100 from 1M to 6M | 1.669 | 0.996 | 2.797 | 0.0518 | |
| CD40:change from BL to 1M | 0.322 | 0.047 | 2.188 | 0.2462 | |
| CD40:change from 1M to 6M | 1.299 | 1.058 | 1.594 | 0.0124 | |
| Selectin:change per 100 from BL to 1M | 0.257 | 0.003 | 25.705 | 0.5635 | |
| Selectin:change per 100 from 1M to 6M | 0.385 | 0.006 | 26.732 | 0.6591 |
Adjustments made for baseline biomarkers, baseline treatment, on/off drug at 6 month and all the covariates in baseline model.