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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: J Am Chem Soc. 2019 Aug 29;141(36):14005–14020. doi: 10.1021/jacs.9b06222

Scheme 3.

Scheme 3.

(A) Two strategies toward the construction of MOC based anticancer drugs. (B) MOCs used as coassembly units for construction MNPs. (C) MOCs uptake by cell due to EPR effect and the target organelles. (D) Three stages of MOCs based anticancer drugs, from size effect, to shape effect and then the synergistic effect. Adapted with permission from refs 21–23, 27–28, 31, 53–55, 57–60, 68 and 90. Copyright 2015, 2017, 2018 and 2019 American Chemical Society, 2017 and 2018 the Royal Society of Chemistry, 2016, 2018 and 2019 National Academy of Sciences (USA), 2016 Wiley-VCH, 2018 Elsevier. 2018 Nature Publishing Group.