Summary of findings'. 'Summary of findings table.
What is the accuracy of the Mini‐Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a secondary care setting? | ||||
Population | Adult patients who completed the Mini‐Cog, with no restrictions on the case mix of recruited participants | |||
Setting | Secondary care settings including outpatient clinics, inpatient general, and specialist hospital settings | |||
Index test | Mini‐Cog includes the Clock Draw Tests and 3‐word recall | |||
Reference standard | Clinical diagnosis of dementia using recognised diagnostic criteria | |||
Studies | Cross‐sectional but not case‐control studies were included | |||
Study |
Summary accuracy (95% CI) |
No. of included participants |
Dementia prevalence |
Implications, quality, and comments |
Clionsky 2010 scoring as per Borson 2000 | Sensitivity: 0.67 (0.63 to 0.71) Specificity: 0.87 (0.81 to 0.92) Positive PV: 0.94 Negative PV: 0.49 |
702 | 73.5% | Only 40% of available records collated from neuropsychology and geriatric psychiatry practice were used to evaluate Mini‐Cog accuracy. Sampling frame, inclusion and exclusion criteria were not described. Mini‐Cog derived from longer cognitive test battery. Included all‐cause dementia and reported dementia subtypes diagnosed. Patient selection ‐ high risk of bias; unclear applicability concerns Index test ‐ unclear risk of bias; high applicability concerns Reference standard ‐ low risk of bias; low applicability concerns Flow and timing ‐ high risk of bias |
Filho 2009 multiple thresholds reported in paper; data quoted with scoring as per Borson 2000 | Sensitivity: 0.60 (0.48 to 0.72) Specificity: 0.65 (0.57 to 0.73) Positive PV: 0.45 Negative PV: 0.78 |
211 | 32.2% | Multiple exclusion criteria including relying on participants providing informed consent. Only 69% of assessed participants included in the analysis. Focused on those who had 4 or fewer years of education. Mini‐Cog derived from longer cognitive test battery. Did not report dementia by subtype diagnosed. Patient selection ‐ high risk of bias; high applicability concerns Index test ‐ unclear risk of bias; high applicability concerns Reference standard ‐ low risk of bias; low applicability concerns Flow and timing ‐ high risk of bias |
Milian 2012 scoring as per Borson 2000 | Sensitivity: 0.87 (0.83 to 0.90) Specificity: 1.00 (0.94 to 1.00) Positive PV: 1.00 Negative PV: 0.52 |
502 | 87.3% | Included individuals admitted to Specialist Memory Clinic setting, but excluded those with depression and mild cognitive impairment which accounts for very high prevalence of dementia. Mini‐Cog derived from longer cognitive test battery. Included all‐cause dementia and reported dementia subtypes diagnosed. Patient selection ‐ high risk of bias; high applicability concerns Index test ‐ unclear risk of bias; high applicability concerns Reference standard ‐ low risk of bias; low applicability concerns Flow and timing ‐ low risk of bias |
95% CI: 95% confidence interval
Positive PV: positive predictive value
Negative PV: negative predictive value