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. 2019 Sep 14;2019(9):CD011414. doi: 10.1002/14651858.CD011414.pub2

Summary of findings'. 'Summary of findings table.

What is the accuracy of the Mini‐Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a secondary care setting?
Population Adult patients who completed the Mini‐Cog, with no restrictions on the case mix of recruited participants
Setting Secondary care settings including outpatient clinics, inpatient general, and specialist hospital settings
Index test Mini‐Cog includes the Clock Draw Tests and 3‐word recall
Reference standard Clinical diagnosis of dementia using recognised diagnostic criteria
Studies Cross‐sectional but not case‐control studies were included
Study Summary accuracy
(95% CI)
No. of included
participants
Dementia
prevalence
Implications, quality, and comments
Clionsky 2010 scoring as per Borson 2000 Sensitivity: 0.67 (0.63 to 0.71)
Specificity: 0.87 (0.81 to 0.92)
Positive PV: 0.94
Negative PV: 0.49
702 73.5% Only 40% of available records collated from neuropsychology and geriatric psychiatry practice were used to evaluate Mini‐Cog accuracy. Sampling frame, inclusion and exclusion criteria were not described. Mini‐Cog derived from longer cognitive test battery. Included all‐cause dementia and reported dementia subtypes diagnosed.
Patient selection ‐ high risk of bias; unclear applicability concerns
Index test ‐ unclear risk of bias; high applicability concerns
Reference standard ‐ low risk of bias; low applicability concerns
Flow and timing ‐ high risk of bias
Filho 2009 multiple thresholds reported in paper; data quoted with scoring as per Borson 2000 Sensitivity: 0.60 (0.48 to 0.72)
Specificity: 0.65 (0.57 to 0.73)
Positive PV: 0.45
Negative PV: 0.78
211 32.2% Multiple exclusion criteria including relying on participants providing informed consent. Only 69% of assessed participants included in the analysis. Focused on those who had 4 or fewer years of education. Mini‐Cog derived from longer cognitive test battery. Did not report dementia by subtype diagnosed.
Patient selection ‐ high risk of bias; high applicability concerns
Index test ‐ unclear risk of bias; high applicability concerns
Reference standard ‐ low risk of bias; low applicability concerns
Flow and timing ‐ high risk of bias
Milian 2012 scoring as per Borson 2000 Sensitivity: 0.87 (0.83 to 0.90)
Specificity: 1.00 (0.94 to 1.00)
Positive PV: 1.00
Negative PV: 0.52
502 87.3% Included individuals admitted to Specialist Memory Clinic setting, but excluded those with depression and mild cognitive impairment which accounts for very high prevalence of dementia. Mini‐Cog derived from longer cognitive test battery. Included all‐cause dementia and reported dementia subtypes diagnosed.
Patient selection ‐ high risk of bias; high applicability concerns
Index test ‐ unclear risk of bias; high applicability concerns
Reference standard ‐ low risk of bias; low applicability concerns
Flow and timing ‐ low risk of bias

95% CI: 95% confidence interval

Positive PV: positive predictive value

Negative PV: negative predictive value