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. Author manuscript; available in PMC: 2020 Sep 15.
Published in final edited form as: Cancer Res. 2019 Jul 26;79(18):4557–4566. doi: 10.1158/0008-5472.CAN-18-3962

Figure 1. Cross Talk in the Tumor Microenvironment.

Figure 1.

A. Depicts the impact of inflammatory or tumor suppressive immune cells on tumor cells in the TME. The bold arrows show the impact that immune cells ideally have on tumor cells (TC). The interactions between NKTs, DCs, T cells, Neutrophils, ILCs, Mφ, and NKs and tumor cells are depicted. Fibroblasts are denoted with the letter ‘F’.

B. Depicts the cross talk between immune cells in the TME that have been polarized to an immune suppressive type, and the cytokines secreted by the TCs that contribute to this Th2-like polarization.