Table 2.

Nine novel protein-prostate cancer associations for proteins whose encoding genes are located at genomic loci within 500kb of previous GWAS-identified prostate cancer risk variants

Protein	Protein name	Protein- encoding gene	Region	Index SNP(s)a	Distance of gene to the index SNP (kb)	Instrument variants	Type of pQTL	ORb	95% CIb	P value	FDR P valuec	P value after adjusting for risk SNPsd
Cathepsin S	Cathepsin S	CTSS	1q21.3	rs17599629	44	rs41271951	cis	0.91	0.88-0.95	2.73 × 10−7	4.99 × 10−5	0.16
MICB	MHC class I polypeptide-related sequence B	MICB	6p21.33	rs2596546	133	rs3134900	cis	1.09	1.05-1.12	2.07 × 10−6	2.76 × 10−4	0.03
RF1ML	Peptide chain release factor 1-like_mitochondrial	MTRF1L	6q25.2	rs3968480	109	rs503366	cis	1.18	1.08-1.29	4.67 × 10−4	0.03	0.21
IGF-II receptor	Cation-independent mannose-6-phosphate receptor	IGF2R	6q25.3	rs651164	47	rs629849	cis	0.92	0.90-0.94	3.98 × 10−10	9.73 × 10−8	9.95 × 10−11
PSP-94	Beta-microseminoprotein	MSMB	10q11.22	rs10993994	0.002	rs541781976, rs10993994	trans,cis	0.81	0.80-0.82	3.60 × 10−155	5.29 × 10−152	NA*
Glutathione S-transferase Pi	Glutathione S-transferase P	GSTP1	11q13.2	rs12785905	399	rs1695, rs62143206	cis,trans	0.94	0.91-0.97	5.91 × 10−4	0.03	3.12 × 10−3
KDEL2	KDEL motif-containing protein 2	KDELC2	11q22.3	rs1800057	199	rs74911261	cis	0.89	0.86-0.93	1.83 × 10−8	3.85 × 10−6	0.42
SPINT2	Kunitz-type protease inhibitor 2	SPINT2	19q13.2	rs8102476 rs12610267	0	rs71354995	cis	1.05	1.03-1.06	1.31 × 10−6	1.92 × 10−4	0.07
DcR3	Tumor necrosis factor receptor superfamily member 6B	TNFRSF6B	20q13.33	rs6062509	33	rs62217798	cis	0.69	0.62-0.77	1.98 × 10−11	5.81 × 10−9	0.05

^aClosest risk variant(s) identified in previous GWAS or fine-mapping studies for prostate cancer risk

^bOR (odds ratio) and CI (confidence interval) per one standard deviation increase in genetically predicted protein

^cFDR P value: false discovery rate (FDR) adjusted p value; associations with a FDR p≤0.05 considered statistically significant

^dusing COJO method(27)

NA*: the adjacent risk variant is the corresponding pQTL