Functions of HDMs in neuronal development and plasticity. Summary of the functions of LSD1, Kdm6b, and Kdm5c at different stages of neuronal development as described in the text. Green arrow or box indicates activation of a process or gene, Red bar or box indicates repression of a process or gene. NSC, neural stem cell. nLSD1, neuronal splice variant of LSD1. IEG, immediate early gene. The lightning bold represents synaptic activity and neuronal action potential firing.