Table 2. Rate Ratio of Multiple Sclerosis According to Within-Person Increase in sNfL.
| Increase in sNfLa | No. (%) | RR (95% CI) | P Valueb | P Valuec | |
|---|---|---|---|---|---|
| Cases | Controls | ||||
| Within-person increase from presymptomatic to postonset samples | |||||
| ≥5 pg/mL | 16 (53.3) | 10 (33.3) | 2.25 (0.69-7.31) | .18 | .71 |
| ≥10 pg/mL | 14 (46.7) | 3 (10.0) | 6.00 (1.34-26.81) | .02 | .08 |
| ≥15 pg/mL | 14 (46.7) | 3 (10.0) | 6.00 (1.34-26.81) | .02 | .08 |
| ≥20 pg/mL | 13 (43.3) | 1 (3.3) | 12.00 (1.56-92.29) | .02 | .07 |
| Within-person increase in presymptomatic samples | |||||
| ≥5 pg/mL | 19 (63.3) | 6 (20.0) | 7.50 (1.72-32.80) | .007 | .03 |
| ≥10 pg/mL | 11 (36.7) | 2 (6.7) | 10.00 (1.28-78.12) | .03 | .11 |
| ≥15 pg/mL | 7 (23.3) | 1 (3.3) | 11.25 (1.15-110.04)d | .04d | .15 |
| ≥20 pg/mL | 6 (20.0) | 1 (3.3) | 9.03 (0.90-90.66)d | .06d | .25 |
Abbreviations: RR, rate ratio; sNfL, serum neurofilament light.
a
The categories are not mutually exclusive.
b
Raw P value.
c
P value adjusted for multiple comparisons using the Bonferroni correction.
d
Estimated using unconditional logistic regression owing to no discordant pairs in cases and matched controls that experienced an increase in sNfL. The model was adjusted for age, sex, and race/ethnicity.