Table 1. Patient and Disease Characteristics of the Analyzed Cohort, Stratified by Receipt of LDLT.
| Characteristic | No. (%) | P Value | |
|---|---|---|---|
| Chemotherapy Alone (n = 2097) | Chemotherapy With LDLT (n = 104) | ||
| Age, median (IQR), y | 63 (55-71) | 61.5 (54-70) | .32a |
| Sex | |||
| Male | 1085 (51.7) | 46 (44.2) | .16b |
| Female | 1012 (48.3) | 58 (55.8) | |
| Race | |||
| White | 1765 (84.2) | 89 (85.6) | .96b |
| Black | 181 (8.6) | 9 (8.7) | |
| Otherc | 123 (5.9) | 5 (4.8) | |
| Unknown | 28 (1.3) | 1 (1.0) | |
| Charlson Comorbidity Index score | |||
| 0 | 1504 (71.7) | 73 (70.2) | .50b |
| 1 | 416 (19.8) | 25 (24.0) | |
| 2 | 108 (5.2) | 5 (4.8) | |
| ≥3 | 69 (3.3) | 1 (1.0) | |
| Insurance status | |||
| No insurance | 84 (4.0) | 5 (4.8) | .26b |
| Private | 900 (42.9) | 48 (46.2) | |
| Government | 1063 (50.7) | 46 (44.2) | |
| Unknown | 50 (2.4) | 5 (4.8) | |
| Treatment facility | |||
| Community cancer program | 130 (6.2) | 5 (4.8) | .67b |
| Comprehensive community cancer program | 723 (34.5) | 30 (28.8) | |
| Academic or research institution | 983 (46.9) | 55 (52.9) | |
| Integrated network cancer program | 198 (9.4) | 10 (9.6) | |
| Unknown | 63 (3.0) | 4 (3.8) | |
| Year of diagnosis, median (IQR) | 2011 (2009-2013) | 2011 (2009- 2013) | .28a |
| T staged | |||
| 1 | 224 (10.7) | 12 (11.5) | .12b |
| 2 | 586 (27.9) | 24 (23.1) | |
| 3 | 350 (16.7) | 28 (26.9) | |
| 4 | 182 (8.7) | 8 (7.7) | |
| Unknown | 755 (36.0) | 32 (30.8) | |
| Primary tumor size, median (IQR), cme | 7.0 (4.4-10.0) | 5.6 (4.0-8.3) | .048a |
| Primary tumor focality | |||
| Unifocal | 340 (16.2) | 20 (19.2) | .52b |
| Multifocal | 616 (29.4) | 26 (25.0) | |
| Unknown | 1141 (54.4) | 58 (55.8) | |
| N staged | |||
| 0 | 689 (32.9) | 32 (30.8) | .78b |
| 1 | 863 (41.2) | 42 (40.4) | |
| Unknown | 545 (26.0) | 30 (32.8) | |
| Bone metastasis | |||
| No | 1262 (60.2) | 62 (59.6) | .70b |
| Yes | 188 (9.0) | 7 (6.7) | |
| Unknown | 647 (30.9) | 35 (33.7) | |
| Lung metastasis | |||
| No | 1055 (50.3) | 62 (59.6) | .004b |
| Yes | 383 (18.3) | 7 (6.7) | |
| Unknown | 659 (31.4) | 35 (33.7) | |
| Distant lymph node metastasis | |||
| No | 1223 (58.3) | 48 (46.2) | .045c |
| Yes | 528 (25.2) | 34 (32.7) | |
| Unknown | 346 (16.5) | 22 (21.2) | |
Abbreviations: IQR, interquartile range; LDLT, liver-directed local therapy.
a
Determined with Mann-Whitney U (Wilcoxon rank sum) test.
b
Determined with Fisher exact test.
c
Includes American Indian, Asian, and Native Hawaiian or Pacific Islander.
d
Classification per the American Joint Committee on Cancer, 7th edition.
e
Patients with available data: chemotherapy alone, 931; chemotherapy with LDLT, 66.