Table 2. Multivariable Cox Proportional Hazards for Overall Mortality Using the Multiply Imputed Data Set.
| Variable | HR (95% CI) | P Value |
|---|---|---|
| Treatment | ||
| Chemotherapy alone | 1 [Reference] | NA |
| Chemotherapy with LDLT | 0.60 (0.48-0.74) | <.001 |
| Age | 1.01 (1.00-1.01) | .003 |
| Sex | ||
| Male | 1 [Reference] | NA |
| Female | 0.86 (0.79-0.95) | .002 |
| Race | ||
| White | 1 [Reference] | NA |
| Black | 1.05 (0.89-1.24) | .54 |
| Other | 1.00 (0.82-1.23) | .98 |
| Charlson Comorbidity Index score | ||
| 0 | 1 [Reference] | NA |
| 1 | 1.23 (1.10-1.38) | <.001 |
| 2 | 1.29 (1.05-1.59) | .014 |
| ≥3 | 1.49 (1.15-1.92) | .002 |
| Insurance status | ||
| No insurance | 1 [Reference] | NA |
| Private | 0.81 (0.63-1.03) | .09 |
| Government | 0.84 (0.65-1.08) | .17 |
| Treatment facility | ||
| Community cancer program | 1 [Reference] | NA |
| Comprehensive community cancer program | 1.01 (0.82-1.25) | .48 |
| Academic or research institution | 0.80 (0.65-0.98) | .03 |
| Integrated network cancer program | 0.92 (0.72-1.16) | .47 |
| Year of diagnosis | 0.98 (0.96-0.996) | .02 |
| T stagea | ||
| 1 | 1 [Reference] | NA |
| 2 | 1.09 (0.85-1.39) | .48 |
| 3 | 1.14 (0.86-1.52) | .35 |
| 4 | 1.21 (0.88-1.68) | .22 |
| Tumor focality | ||
| Unifocal | 1 [Reference] | NA |
| Multifocal | 1.01 (0.83-1.22) | .93 |
| N stagea | ||
| 0 | 1 [Reference] | NA |
| 1 | 1.06 (0.95-1.17) | .28 |
| Bone metastasis | ||
| No | 1 [Reference] | NA |
| Yes | 1.30 (1.03-1.65) | .02 |
| Lung metastasis | ||
| No | 1 [Reference] | NA |
| Yes | 1.24 (1.07-1.44) | .004 |
| Distant lymph node metastasis | ||
| No | 1 [Reference] | NA |
| Yes | 0.90 (0.79-1.03) | .13 |
Abbreviations: HR, hazard ratio; LDLT, liver-directed local therapy; NA, not applicable.
a
Classification per the American Joint Committee on Cancer, 7th edition.