Table 2.
Univariate and multivariate analyses of disease-free survival and cancer-specific survival for upper tract urothelial carcinomas.
| Variables | Item | Disease-free survival | Cancer-specific survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||||||||
| HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | ||
| Stage | III/IV | 1.76 | 1.01-3.08 | 0.046 | 1.18 | 0.57-2.44 | 0.661 | 6.03 | 2.17-16.80 | 0.001 | 4.18 | 1.00-17.51 | 0.051 |
| I/II | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| Grade | High | 1.15 | 0.61-2.17 | 0.659 | 1.05 | 0.50-2.22 | 0.902 | 1.65 | 0.55-4.99 | 0.376 | 0.63 | 0.14-2.86 | 0.547 |
| Low | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| Gender | Male | 1.24 | 0.71-2.16 | 0.456 | 1.18 | 0.64-2.16 | 0.596 | 1.36 | 0.55-3.36 | 0.501 | 0.89 | 0.32-2.43 | 0.815 |
| Female | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| Age (years) | ≥65 | 1.68 | 0.92-3.05 | 0.091 | 1.54 | 0.78-3.07 | 0.216 | 1.43 | 0.54-3.77 | 0.470 | 1.11 | 0.33-3.72 | 0.870 |
| <65 | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| Tumor location | Renal pelvis + ureter | 1.39 | 0.68-2.83 | 0.364 | 1.47 | 0.64-3.37 | 0.365 | 1.11 | 0.37-3.32 | 0.856 | 1.33 | 0.31-5.82 | 0.701 |
| Renal pelvis | 0.76 | 0.40-1.45 | 0.406 | 0.67 | 0.34-1.31 | 0.243 | 0.56 | 0.19-1.68 | 0.301 | 0.42 | 0.13-1.34 | 0.143 | |
| Ureter | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| Tumor side | Left | 0.80 | 0.46-1.40 | 0.443 | 0.84 | 0.46-1.55 | 0.584 | 0.59 | 0.24-1.48 | 0.263 | 0.43 | 0.14-1.29 | 0.131 |
| Right | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| Lymphovascular invasion | Positive | 1.35 | 0.72-2.55 | 0.351 | 1.13 | 0.54-2.39 | 0.745 | 2.49 | 0.97-6.34 | 0.057 | 2.15 | 0.69-6.70 | 0.186 |
| Negative | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| Creatinine (mg/dl) | >1.5 | 1.06 | 0.60-1.88 | 0.844 | 0.93 | 0.50-1.73 | 0.822 | 0.76 | 0.29-2.00 | 0.570 | 0.59 | 0.19-1.76 | 0.342 |
| ≤1.5 | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
|
| |||||||||||||
| CSF-1 | High | 2.14 | 1.20-3.81 | 0.010 | 2.56 | 1.30-5.04 | 0.007 | 5.18 | 1.71-15.71 | 0.004 | 5.14 | 1.27-20.84 | 0.022 |
| Low | 1.00 | 1.00 | 1.00 | 1.00 | |||||||||
Abbreviations: HR: hazard ratio; CI: confidence interval.