Table 2. Effect of His₆-OPH combination with antibiotics on the interaction energy of AHLs as substrates with the enzyme.

Enzyme or combinations	Interaction energy, kJx mol−1
	S1*	S2	S3
His6-OPH	−25.05  ± 7.38	−57.51  ± 12.08	−153.62  ± 8.60
His6-OPH/A1**	−72.27  ± 11.97	−227.60  ± 15.01	−138.44  ± 7.58
His6-OPH/A2	−86.60  ± 3.06	−109.52  ± 12.18	−129.67  ± 6.52

Notes.

^*S₁, S₂, S₃ are C4-, C8- and C12-HSLs, respectively.

^**A₁, A₂ are puromycin and ceftiofur, respectively.