. 2019;20(7):1951–1957. doi: 10.31557/APJCP.2019.20.7.1951

Table 2.

Summary Risk Estimates for Association between IL-10 Polymorphism and Risk of Lung Cancer

Subgroup	Genetic Model	Type of Model	Heterogeneity			Odds Ratio (OR)			Publication Bias
			I² (%)	P_H	OR	95% CI	Z_OR	P_OR	P_Beggs
-592A>C	C vs. A	Fixed	49.9	0.06	1.14	1.03-1.25	2.68	0.007	1
	CC vs. AA	Fixed	0	0.68	1.64	1.29-2.02	4.16	≤0.001	0.54
	CA vs. AA	Fixed	37.21	0.14	1.26	1.06-1.50	2.68	≤0.001	0.22
	CC+CA vs. AA	Fixed	15.63	0.31	1.31	1.11-1.54	3.27	0.001	0.36
	CC vs. CA+AA	Random	62.3	0.01	1.16	0.89-1.52	1.12	0.26	0.54
Asians	C vs. A	Fixed	43.73	0.14	1.26	1.11-1.43	3.61	≤0.001	0.73
	CC vs. AA	Fixed	17.91	0.3	1.61	1.22-2.21	3.43	0.001	0.73
	CA vs. AA	Fixed	20.93	0.28	1.16	0.96-1.40	1.58	0.11	1
	CC+CA vs. AA	Fixed	35.76	0.19	1.25	1.04-1.49	2.49	0.01	1
	CC vs. CA+AA	Fixed	0	0.4	1.52	1.19-1.93	3.41	0.001	0.73
Caucasians	C vs. A	Fixed	0	0.67	0.99	0.85-1.15	-0.09	0.92	1
	CC vs. AA	Fixed	0	0.89	1.7	1.09-2.65	2.36	0.01	1
	CA vs. AA	Fixed	0	0.85	2.08	1.32-3.27	3.18	0.001	0.29
	CC+CA vs. AA	Fixed	0	0.81	1.76	1.13-2.71	2.54	0.01	1
	CC vs. CA+AA	Fixed	0	0.4	1.52	1.19-1.93	3.41	0.001	0.73
-819T>C	T vs. C	Random	95.76	≤0.001	0.98	0.86-1.11	-0.25	0.8	0.8
	TT vs. CC	Random	87.95	≤0.001	1.53	0.57-4.06	0.85	0.39	0.8
	TC vs. CC	Fixed	19.96	0.28	1.01	0.84-1.22	0.16	0.87	0.8
	TT+TC vs. CC	Random	94.81	≤0.001	0.71	0.30-1.71	-0.74	0.45	0.8
	TT vs. TC+CC	Random	92.33	≤0.001	0.98	0.33-2.41	-0.04	0.96	0.8
-1082A>G	G vs. A	Random	90.8	≤0.001	1.51	0.95-2.38	1.76	0.07	0.13
	GG vs. AA	Random	71.79	≤0.001	1.15	0.63-2.08	0.46	0.64	0.46
	GA vs. AA	Random	88.58	≤0.001	1.67	0.92-3.04	1.7	0.08	0.45
	GG+GA vs. AA	Random	89.81	≤0.001	1.76	0.97-3.20	1.86	0.06	0.76
	GG vs. GA+AA	Fixed	53.87	0.07	1.02	0.81-1.30	0.23	0.81	0.8
Asians	G vs. A	Random	95.29	≤0.001	1.64	0.63-4.22	1.03	0.3	1
	GG vs. AA	Random	80.06	0.02	0.79	0.29-2.10	-0.46	0.64	NA
	GA vs. AA	Random	92.73	≤0.001	1.56	0.60-4.03	0.91	0.36	1
	GG+GA vs. AA	Random	92.97	≤0.001	1.68	0.65-4.32	1.07	0.28	0.73
	GG vs. GA+AA	Random	73.27	0.05	0.83	0.36-1.91	-0.42	0.67	NA
Caucasians	G vs. A	Random	82.69	0.003	1.46	0.82-2.59	1.31	0.18	1
	GG vs. AA	Random	73.42	0.02	1.72	0.59-5.00	1	0.31	1
	GA vs. AA	Random	87.66	≤0.001	1.95	0.61-6.24	1.13	0.25	1
	GG+GA vs. AA	Random	87.64	≤0.001	1.99	0.65-6.08	1.21	0.22	1
	GG vs. GA+AA	Fixed	36.07	0.2	1.14	0.86-1.51	0.93	0.35	1