Table 2.
Univariate Analysis of Possible Prognostic Factor
| Variables | N | Median survival (mo.) | P-value | |
|---|---|---|---|---|
| Age | >60 <60 |
19 50 |
23.3 (6.30,40.26) 10.2 (5.23,15.16) |
0.221 |
| Underlying disease |
No Yes |
52 17 |
9.9 (4.48,15.31) 14.5 (9.66,19.34) |
0.313 |
| ECOGa | 0-1 2 |
52 17 |
14.7 (10.98,18.41) 7.2 (3.16, 11.23) |
<0.001 |
| Primary Site |
Larynx Hypopharynx |
28 41 |
14.5 (12.0-17.0) 8.5 (5.3,11.7) |
0.504 |
| Patho | SCCb Non SCC |
63 6 |
12.2 (7.86,16.53) 6.8 (0,45.49) |
0.709 |
| T stage | T1 T2 T3 T4 |
7 14 22 26 |
Not reach 12.8 (6.93,18.66) 7.8 (0,15.95) 7.2 (4.70,9.69) |
0.133 |
| N stage | N0 N1 N2 N3 |
22 18 18 11 |
12.2 (4.59, 19.80) 23.3 (11.45,35.15) 7.20 (5.67,8.72) 5.1 (0.50, 9.69) |
0.01 |
| Group stage | III IV |
25 44 |
23.3 (11.25, 35.34) 7.6 (4.89,10.30) |
0.024 |
| Volume | <10ml >=10ml unknown |
36 21 10 |
16.6 (4.67,28.53) 8.2 (5.21,11.19) |
0.147 |
| Cord Involvement |
No Unilateral Bilateral |
41 26 2 |
16.4 (10.17,22.63) 7.6 (4.60,10.60) 3.0 |
0.042 |
| Cord Fixation |
No Yes |
51 18 |
14.5 (10.13,18.87) 7.2 (5.95,8.45) |
0.245 |
| UAOc | No Yes |
54 15 |
14.7 (10.20,19.20) 7.20 (6.58, 7.82) |
0.007 |
| Dose | 45-50 Gy 51-60 Gy 61-70 Gy |
14 2 53 |
7.2 (5.46,8.94) 1.6 15.4 (9.69,21.11) |
<0.001 |
| Treatment Break |
None ≤ 1 wk >1-2 wk |
49 18 2 |
35.6 (9.06,18.94) 8.2 (3.63,12.77) 8.5 |
0.741 |
| Type of CMTd | Cis/carbo weekly Cis/carbo+5FU Other None |
49 7 1 12 |
14.5 (10.93,18.07) 7.6 (0,17.87) 14.0 |
0.086 |
| Smoking Continuation |
No Yes |
66 3 |
12.2 (7.82,16.51) 7.2 |
0.461 |
| Alcohol continuation |
No Yes |
68 1 |
11.1 (6.55,15.65) 16.4 |
0.970 |
| Salvage surgery | No Yes |
63 6 |
9.9 (5.45,14.34) 42.0 (14.6,69.40) |
0.073 |
| Recurrence | No Yes |
33 36 |
14.0 (1.55,26.44) 10.2 (4.76,15.63) |
0.070 |
| Larynx preserve |
No Yes |
35 34 |
11.1 (5.42,16.77) 12.8 (1.94,23.65) |
0.099 |
| Distant Metastases |
No Yes |
62 7 |
11.1 (6.27,15.92) 12.8 (0,28.45) |
0.579 |
a
, Eastern Cooperative Oncology group (ECOG) performance status scale;
b
, Squamous cell carcinoma;
c
, upper airway obstruction;
d
, chemotherapy.