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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Aug 20;29(19):126628. doi: 10.1016/j.bmcl.2019.126628

Table 1.

Inhibitory activities of the first iteration of purine analogs with variation at the N6-position.

graphic file with name nihms-1538118-t0001.jpg
Compound R IP6K1 pIC50
1, TNP graphic file with name nihms-1538118-t0002.jpg < 3.70*
4 graphic file with name nihms-1538118-t0003.jpg < 3.70
5 graphic file with name nihms-1538118-t0004.jpg < 3.70
6 graphic file with name nihms-1538118-t0005.jpg 3.93 ± 0.10
*

Solubility issues preclude proper IC50 determination

Data represented as the mean ± SEM.