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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Aug 20;29(19):126628. doi: 10.1016/j.bmcl.2019.126628

Table 2.

Inhibitory activities of the second iteration of purine analogs with variation at the N2-position.

graphic file with name nihms-1538118-t0006.jpg
Compound R IP6K1 pIC50
7 graphic file with name nihms-1538118-t0007.jpg 4.10 ± 0.12
8 graphic file with name nihms-1538118-t0008.jpg 4.05 ± 0.04
9 graphic file with name nihms-1538118-t0009.jpg 4.95 ± 0.19
10 graphic file with name nihms-1538118-t0010.jpg 5.08 ± 0.10
11 graphic file with name nihms-1538118-t0011.jpg 4.03 ± 0.09
12 graphic file with name nihms-1538118-t0012.jpg < 3.70

Data represented as the mean ± SEM.