Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Aug 20;29(19):126628. doi: 10.1016/j.bmcl.2019.126628

Table 3.

Inhibitory activities of the third iteration of purine analogs with exploration around an N2-tryptamine.

graphic file with name nihms-1538118-t0013.jpg
Compound R1 R2 R3 n IP6K1 pIC50
13 H OMe H 1 3.86 ± 0.08
14 H OH H 1 4.50 ± 0.14
15 H Cl H 1 4.57 ± 0.20
16 H Me H 1 3.91 ± 0.08
17 H H OMe 1 5.56 ± 0.09
18 Me H H 1 5.71 ± 0.14
19 H H H 2 4.16 ± 0.01

Data represented as the mean ± SEM.