Table 5.
Compound 24 thermally stabilizes IP6K1 to a greater degree than other purine analogs.
| Compound | ΔTm at 11.1μM (°C) | ΔTmMax (°C) |
|---|---|---|
| 24 | 5.5 | 6.6 ± 0.6 |
| 17 | 3.6 | 4.7 ± 0.6 |
| 10 | 2.4 | 4.3 ± 0.9 |
| 1, TNP | 1.8 | 3.3 ± 0.6 |
Data represented as the mean ± SEM.
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