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. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Bioorg Med Chem Lett. 2019 Aug 20;29(19):126628. doi: 10.1016/j.bmcl.2019.126628

Table 7.

Comparison of compound 24 with TNP

Parameter	Compound 24	TNP, 1
Nitrobenzyl	Removed	Present
Solubility	51μg/mL (PBS pH 7.4)	Mostly insoluble in 2% DMSO
Potency	0.20μM K_i	0.24μM K_i (published value)^*
IP6K selectivity	24.4 fold over K2 48.1 fold over K3	Not selective^*
Microsome stability (t_1/2)	Rat 38 min	Mouse 9 min^**
Microsome stability (t_1/2)	Human 42 min	Human 32 min^**

^*

published in Padmanabhan, et al. J Biol Chem 2009

^**

published in Ghoshal, et al. Mol Metab. 2016