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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Neuropharmacology. 2019 Jul 26;158:107727. doi: 10.1016/j.neuropharm.2019.107727

Figure 6. Effect of intranasal administration of r-Slit2 on brain infarct area and short-term neurological function at 48h post HIE.

Figure 6.

(A–B) TTC staining showed that low dose (10ug/kg) of r-Slit2 treatment significantly reduced infarct area when compared to vehicle. (C–D) Righting reflex and Geotaxis reflex showed that low dose (10ug/kg) of r-Slit2 significantly improved neurological function compared to vehicle animals. (E) Animals’ weight change after HIE. Statistical differences between groups were analyzed using one-way or two-way ANOVA followed by Tukey multiple-comparison post hoc analysis. * versus sham; # versus vehicle (n=6/group).